NucresiranRNAi therapeutic / Transthyretin Amyloidosis (TTR) ATTR Amyloidosis with CardiomyopathyPhase 3hATTR Amyloidosis with PolyneuropathyPhase 3
HypertensionPhase 3REVERSIR HypertensionPhase 1
RapirosiranALN-HSD / HSD / RNAi therapeutic / Metabolic Metabolic Dysfunction-Associated Steatohepatitis (MASH)Phase 2
ALN-ANG3ALN-ANG3 / ANG3 / RNAi therapeutic / Metabolic Diabetic Kidney DiseasePhase 2
ALN-4324ALN-4324 / GRB14 / RNAi therapeutic / Metabolic Type 2 Diabetes MellitusPhase 1
ALN-2232ALN-2232 / ACVR1C / RNAi therapeutic / Metabolic Obesity & Weight ManagementPhase 1
ALN-PNPALN-PNP / PNP / RNAi therapeutic / Metabolic Non-Alcoholic Fatty Liver Disease (NAFLD)Phase 1
ALN-APOC3ALN-APOC3 / APOC3 / RNAi therapeutic / Metabolic DyslipidemiaPhase 1
ALN-CIDEBALN-CIDEB / CIDEB / RNAi therapeutic / Metabolic Metabolic Dysfunction-Associated Steatohepatitis (MASH)Phase 1
Myasthenia GravisPhase 3Geographic AtrophyPhase 3
MivelsiranALN-APP / APP / RNAi therapeutic / Neuroscience Cerebral Amyloid Angiopathy (CAA)Phase 2Alzheimer’s DiseasePhase 1
ALN-HTT02ALN-HTT02 / HTT / RNAi therapeutic / Neuroscience Huntington’s DiseasePhase 1
ALN-5288ALN-5288 / MAPT / RNAi therapeutic / Neuroscience Alzheimer’s DiseasePhase 1
ALN-SODALN-SOD / SOD1 / RNAi therapeutic / Neuroscience SOD1 Amyotrophic Lateral Sclerosis (ALS)Phase 1
ALN-SNCAALN-SNCA / SNCA / RNAi therapeutic / Neuroscience Parkinson’s DiseasePhase 1
Paroxysmal Nocturnal HemoglobinuriaPhase 3
ALN-6400ALN-6400 / PLG / RNAi therapeutic / Hematology Bleeding DisordersPhase 2
AG-236ALN-TMP / TMP / RNAi therapeutic / Hematology Polycythemia VeraPhase 1
ALN-CFBALN-CFB / CFB / RNAi therapeutic / Hematology Paroxysmal Nocturnal HemoglobinuriaPhase 1
Hepatitis D Virus InfectionPhase 2
ALN-BCATALN-BCAT / BCAT / RNAi therapeutic / Other Hepatocellular CarcinomaPhase 1
ALN-4285ALN-4285 / RNAi therapeutic / Other Healthy VolunteersPhase 1
ALN-4915ALN-4915 / RNAi therapeutic / Other Healthy VolunteersPhase 1
ALN-F1202ALN-F1202 / RNAi therapeutic / Other Healthy VolunteersPhase 1