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Aprea Therapeutics, Inc.

Pipeline3 assets

  • APR-1051APR-1051 / WEE1 kinase / Oral small-molecule WEE1 inhibitor / Oncology
    CCNE1, CCNE2, FBXW7, PPP2R1A advanced solid tumorsPhase 1Monotherapy; potential safety/efficacy clinical data 2Q 2026; complete dose escalation 2Q 2027HPV+ oropharyngeal squamous cell carcinoma; cervical, vaginal or vulvar squamous cell carcinomaPhase 1MonotherapyKRAS G12/13 & TP53 colorectal cancerPhase 1Monotherapy
  • ATRN-119ATRN-119 / Mosipasertib / ATR / Oral macrocyclic small-molecule ATR inhibitor / Oncology
    ATRi synthetic lethal gene alterations in advanced solid tumors (ovarian, CRC, lung)Phase 1/2aMonotherapy; RP2D determinedHematological cancers (AML, MDS)Phase 1/2aMonotherapy; RP2D determined
  • APR-1602APR-1602 / DYRK1 / Oral small-molecule DYRK1 inhibitor / Oncology
    Solid tumors and hematological cancersIND-enablingReady to enter IND-enabling studies; milestone 4Q 2026

Latest news9 items

All news

Aprea Therapeutics to Present at October Conferences

Company to participate in 2026 Maxim Growth Summit (October 14) and Regional Biotechnology Conference (October 15) DOYLESTOWN, Pa., Oct. 05, 2026 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on

Aprea Therapeutics to Present Updated Interim Phase 1 Data on WEE1 Inhibitor APR-1051 in an Oral Presentation at 38th EORTC-NCI-AACR Symposium

DOYLESTOWN, Pa., Sept. 22, 2026 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers, today announced

Presentation / Abstract • Phase 1Oral presentation Fri, Nov 20, 2026, 3:00 PM CET

Aprea Therapeutics Announces Second Quarter 2026 Financial Results

Enrollment in the ongoing Phase 1 dose escalation ACESOT-1051 trial of oral WEE1 inhibitor APR-1051 is accelerating as dose escalation advances Aprea plans to advance APR-1051 in uterine serous carcinoma (USC), and Cyclin E–overexpressing platinum-resistant ovarian cancer (PROC) while also

Presentation / Abstract • Phase 1ASCO poster presentation Sat, May 30, 2026

Aprea Therapeutics Provides ACESOT-1051 Program Update for WEE1 Inhibitor APR-1051: Accelerating and Expanding Enrollment. Clinical Data Presentation Planned for Q4 2026

Next clinical data update from the ongoing Phase 1 dose escalation ACESOT-1051 trial anticipated at a medical meeting in Q4 2026, providing a near-term opportunity to demonstrate continued clinical progress with APR-1051 Enrollment in ACESOT-1051 is accelerating as the Company advances dose

Presentation / Abstract • Phase 1presentation Thu, Jul 30, 2026

Aprea Therapeutics Presents Updated Phase 1 Data on WEE1 Inhibitor APR-1051 at ASCO 2026, Demonstrating Early Monotherapy Activity and Manageable Tolerability in Advanced Solid Tumors

Presentation highlights early clinical activity from ACESOT-1051, including partial responses and stable disease in patients across multiple tumor types Manageable tolerability confirmed across cohorts Patient expansion into uterine serous carcinoma and platinum-resistant ovarian cancer underway;

Presentation / Abstract • Phase 1ASCO poster presentation Sat, May 30, 2026

Aprea Therapeutics Reports First Quarter 2026 Financial Results and Provides a Corporate Update

Oversubscribed $30 million private placement closed, with proceeds expected to support ongoing development of APR-1051 Two partial responses observed with continued encouraging tolerability in the ongoing Phase 1 dose escalation ACESOT-1051 trial of WEE1 inhibitor APR-1051 Additional clinical data

Presentation / Abstract • Phase 1ASCO poster presentation Sat, May 30, 2026, 1:30 PM CT
Aprea Therapeutics, Inc. • Endpoint Arena