PlozasiranARO-APOC3 / REDEMPLO / APOC3 / RNAi therapeutic / Cardiometabolic Familial chylomicronemia syndromeIn MarketSevere hypertriglyceridemiaPhase 3ActiveHypertriglyceridemiaPhase 3Active
ZodasiranARO-ANG3 / ANGPTL3 / RNAi therapeutic / Cardiometabolic Homozygous familial hypercholesterolemiaPhase 3Recruiting
OlpasiranAMG 890; ARO-LPA / LPA / RNAi therapeutic / Cardiovascular disease Elevated lipoprotein(a)/cardiovascular riskPhase 3Recruiting/Active
GSK4532990ARO-HSD / HSD17B13 / RNAi therapeutic / Liver disease MASH/NASHPhase 2Recruiting
ARO-PNPLA3JNJ-75220795 / PNPLA3 / RNAi therapeutic / Liver disease MASH/NASHPhase 1
ARO-INHBEINHBE/Activin E / RNAi therapeutic / Obesity/metabolic disease Obesity with or without type 2 diabetesPhase 1
ARO-ALK7ACVR1C/ALK7 / RNAi therapeutic / Obesity/metabolic disease Obesity with or without type 2 diabetesPhase 1Recruiting
ARO-MAPTMAPT/tau / RNAi therapeutic / CNS Alzheimer's diseasePhase 1Recruiting
Spinocerebellar ataxia 2Phase 1
SRP-1005ARO-HTT / HTT / siRNA therapeutic / CNS Huntington's diseasePhase 1
ARO-RAGERAGE / RNAi therapeutic / Pulmonary Inflammatory pulmonary diseasesPhase 2Active
ARO-MMP7MMP7 / RNAi therapeutic / Pulmonary Idiopathic pulmonary fibrosisPhase 1
FazirsiranTAK-999; ARO-AAT / Z-AAT / RNAi therapeutic / Liver disease Alpha-1 antitrypsin deficiency-associated liver diseasePhase 3Recruiting
ARO-HBVJNJ-3989; JNJ-73763989 / HBV gene products / RNAi therapeutic / Infectious disease Chronic hepatitis BPhase 2
ARO-DUX4DUX4 / RNAi therapeutic / Muscular disease Facioscapulohumeral muscular dystrophyPhase 2
ARO-DM1DMPK mRNA / RNAi therapeutic / Muscular disease Myotonic dystrophy type 1Phase 2Recruiting
ARO-C3Complement component 3 / RNAi therapeutic / Complement mediated disease Complement-mediated renal diseasePhase 1RecruitingC3 glomerulopathyPhase 1RecruitingIgA nephropathyPhase 1Recruiting
ARO-CFBComplement factor B / RNAi therapeutic / Complement mediated disease Complement mediated diseasePhase 1