Vepdegestrant (ARV-471/PF-07850327) + Palbociclib vs Letrozole +
Will this trial show a positive result on Phase 3: Progression-Free SurvivalOutcome measureProgression-Free Survival (PFS)Progression-free survival is defined as the time interval from the date of randomization to the date of first documented tumor progression determined by Blinded Independent Central Review (BICR) as per Response Evaluation Criteria in Solid Tumors (RECIST version 1.1) or death due to any cause, whichever come first.Primary outcome | From randomization date, every 12 weeks, to date of first documentation of progression or death, up to approximately 4 years.ClinicalTrials.gov outcome?
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ER-Positive, HER2-Negative Advanced Breast Cancer
This advanced breast cancer uses estrogen to grow, lacks excess HER2 protein, and has spread or cannot be removed locally. Progression-free survival shows how long treatment prevents cancer from worsening, delaying the need for another treatment.