Fianlimab/cemiplimab for melanoma (HARMONY)
Regeneron Pharmaceuticals
This study is researching an experimental drug called fianlimab (also known as REGN3767), combined with another medication called cemiplimab (also known as REGN2810)...
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16 open trials · Source-linked endpoints · Simulated markets
Current trials 16
Sacituzumab tirumotecan for lung cancer (TroFuse-004)
Merck Sharp & Dohme LLC
This study will evaluate sacituzumab tirumotecan versus chemotherapy (docetaxel or pemetrexed) for the treatment of previously-treated non-small cell lung cancer...
A Study Evaluating Sotorasib Platinum Doublet Combination Versus
Amgen
The primary objectives are to compare progression-free survival (PFS) and overall survival (OS) in people who receive sotorasib with platinum doublet chemotherapy...
Milvexian for atrial fibrillation (LIBREXIA-AF)
Janssen Research & Development, LLC
This study will evaluate if milvexian is at least as effective as apixaban for reducing the risk of the composite stroke and non-central nervous system (CNS) systemic...
Inavolisib for HER2-positive breast cancer (INAVO122)
Hoffmann-La Roche
This study will evaluate the efficacy and safety of inavolisib in combination with Phesgo (pertuzumab, trastuzumab, and rHuPH20 injection for subcutaneous use)...
KarXT for Alzheimer’s psychosis (ADEPT-4)
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
This study will evaluate the safety and efficacy of KarXT in adult people with mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD.
Balcinrenone/dapagliflozin for heart failure (BalanceD-HF)
AstraZeneca
This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with...
A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy
Aura Biosciences
The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate...
Felzartamab for IgA nephropathy
Biogen
In this study, researchers will learn more about the use of felzartamab in people with immunoglobulin A nephropathy (IgAN).
Retatrutide vs tirzepatide for obesity (TRIUMPH-5)
Eli Lilly and Company
The main purpose of this study is to evaluate the efficacy and safety of retatrutide compared to tirzepatide in adults who have obesity.
Tenapanor for chronic constipation (ACCEL)
Ardelyx
This is a 26-week, multi-center, randomized, double-blind, placebo-controlled study with a 4-week treatment-free Safety Follow-up period to assess the safety and...
Vepdegestrant (ARV-471/PF-07850327) + Palbociclib vs Letrozole +
Pfizer
This study will understand the safety and effects of the study medicine vepdegestrant (ARV-471/PF-07850327) given together with palbociclib in advanced breast cancer.
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With
Sanofi
The purpose of each study is to independently measure the annualized relapse rate (ARR) with administration of frexalimab compared to a daily oral dose of...
Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in
Incyte Corporation
This study will evaluate the efficacy and safety of ruxolitinib cream in people with hidradenitis suppurativa.
Efficacy Against Oral Persistent Infection, Immunogenicity and
Merck Sharp & Dohme LLC
This study will evaluate the efficacy, immunogenicity and safety of the 9vHPV vaccine in men 20 to 45 years of age.
Ruxolitinib cream for childhood vitiligo
Incyte Corporation
This study will evaluate the efficacy and safety of ruxolitinib cream in children (6 to \< 12 years old) with nonsegmental vitiligo.