Sacituzumab tirumotecan for lung cancer (TroFuse-004)
Trial
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Will this trial show a positive result on overall Survival (OSOutcome measureOverall Survival (OS)OS is defined as the time from randomization to death due to any cause.Primary outcome | Up to approximately 41 monthsClinicalTrials.gov outcome) of Participants with NSCLC with Epidermal Growth Factor Receptor (EGFR) Mutations?
YES46¢
NO54¢
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- Primary Completion
- 5/10/27
- Study Completion
- 3/11/30
- Sponsor
- Ticker
- $MRK
- Type
- Trial Status
- Active Not Recruiting
- Trial Size
- 556
- NCT
- NCT06074588
- Trial Description
- The purpose of this study is to evaluate sacituzumab tirumotecan versus chemotherapy (docetaxel or pemetrexed) for the treatment of previously-treated non-small cell lung cancer (NSCLC) with exon 19del or exon 21 L858R EGFR mutations (hereafter referred to as EGFR mutations or EGFR-mutated) or any of the follow genomic alterations: ALK gene rearrangements, ROS1 rearrangements, BRAF V600E mutations, NTRK gene fusions, MET exon 14 skipping mutations, RET rearrangements, or less common EGFR point mutations of exon 20 S768I, exon 21 L861Q, or exon 18 G719X mutations. The primary hypothesis is that sacituzumab tirumotecan is superior to chemotherapy with respect to overall survival (OS) in NSCLC with EGFR mutations.